Formulation and Evalution of Irbesartan Liquisolid Tablets

The main objective of this study is to improve the dissolution and there by availability of Irbesartan a practically insoluble drug by liquisolid Compact technique. The liquisolid tablets of Irbesartan were prepared by using various ratio of carrier (Avicel PH 102) to coating (Cab-O-Sil M5) material using PEG 400 as non volatile solvent. The prepared liquisolid tablets were evaluated for hardness, friability, disintegration time. The dissolution profile of Irbesartan tablets were determines according to USP method and compared to that of a direct compressible tablet. The formulated liquisolid system of Irbesartan exhibited acceptable flowability and compressibility. All the formula of liquisolid tablets showed more than 90% release within 60 minutes. Technique of Liquisolid tablet of Irbesartan which can be scaled-up industrially is promising approach for enhancing solubility and dissolution rate. This was due to an increase in wetting properties and surface of drug available for dissolution.